Barcelona are in talks with the American National Women’s Soccer League (NWSL) about entering a team for 2018.
The Catalan club opened a permanent office in New York in September, and have six academies across the US.
A statement from Barcelona said they had “approved a development plan for women’s football in the US… in order to participate in the NWSL from 2018”.
There are 10 franchises in the NWSL, which has never had a European side competing.
But the NWSL confirmed it “looked forward to continuing discussions” with Barcelona over the move.
The Catalan club’s current team are joint-top of the Spanish top tier – which contains a mixture of full-time and semi-professional teams – with two matches remaining.
The team, founded in 1988, reached the last four of the Champions League for the first time this term before losing 5-1 on aggregate to Paris Saint Germain.